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Contraindicated (one)pentobarbital will lower the extent or impact of roflumilast by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases amounts of elvitegravir/cobicistat/emtricitabine/tenofovir DF by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Could bring on loss of virologic reaction and po